Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

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Numerous individuals search for a “cannabis store near me” to acquire marijuana, whether for therapeutic purposes or recreational enjoyment. It is widely recognized that cannabis products can aid in alleviating symptoms such as anxiety, depression, pain, nausea, and vomiting. Have you ever contemplated its impact on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids in the plant interact through the endocannabinoid system in the GI tract.
• cannabis and pain medications can assist in managing Irritable Bowel Syndrome symptoms.
• Speed Greens Canada offers a variety of cannabis Sativa products, known for both recreational and medical uses.

Gastrointestinal Disorders and the Cannabis Plant

The dietary impacts of nutraceuticals on gastrointestinal (GI) health are well recognized. Certain dietary patterns show promise in preventing or alleviating various GI conditions. Researchers have identified and evaluated the food components responsible for these benefits.

Among the plant-derived nutraceuticals that may be beneficial for treating GI disorders are those sourced from cannabis. cannabis refers to products derived from the cannabis Sativa plant, an aromatic flowering herb.

According to John M. McPartland, the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the cannabis genus, Sativa consists of three varieties: Sativa, Indica, and Ruderalis. Notably, depending on the variety, cannabis Sativa serves multiple purposes, including fiber production, oil extraction from seeds, and primarily recreational or medicinal applications.

The Impact of the Plant

Receptors and ligands of the endocannabinoid system are present throughout various areas and systems, both within and beyond the GI tract, relevant to regulating GI functions. The presence of cannabinoid receptors allows cannabinoids, including non-psychoactive phytocannabinoids, to modulate GI functions in health and disease. The ECS plays a role in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has multiple contributing factors, affecting 10–20% of individuals in developed nations, manifesting as functional gastrointestinal disturbances without identifiable organic origins.

The enhancement of the antinociceptive properties of cannabinoids amid inflammation highlights the importance of the ECS in visceral hypersensitivity. This insight not only clarifies the mechanisms behind conditions like IBS and other gastrointestinal disorders but also suggests promising therapeutic pathways for alleviating abdominal and visceral pain.

Cannabinoids alone may not provide substantial relief in reducing visceral hypersensitivity among IBS patients. Investigating combinations with other pain-modulating agents, such as opioids, presents an intriguing alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition of the GI tract, arising from environmental, genetic, and epigenetic factors.

Cannabidiol showcases significant anti-inflammatory effects across various models of intestinal inflammation in animals, as noted in a study published in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated a dose-dependent improvement in disease indicators:

• A reduction in structural damage
• A decrease in inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal indicated that the main finding of their investigation was the challenging tolerability of the botanical extract, with 90% of patients reporting treatment-related adverse effects compared to 48% receiving the placebo.

A trend emerged toward improved quality of life scores and a positive change in patients’ overall impressions, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract may provide therapeutic benefits to those patients who can endure its effects.

Gastrointestinal Cancer

GI cancers, such as colorectal cancer (CRC), are among the most commonly diagnosed conditions in the general population.

Various studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD may protect DNA from oxidative stress, enhance endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.

The confirmation of CBD’s chemopreventive properties was observed through in vivo models focused on AOM-induced colon cancer. A dosage of 1 mg/kg resulted in a significant reduction: ACF decreased by 67%, while the number of tumors and polyps fell by 66% and 57%, respectively. Increasing the concentration to 5 mg/kg showed efficacy primarily in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

Positive effects of CBD occur when combined with THC, as shown in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may arise from the indirect stimulation of somatodendritic 5-HT1A receptors located in the dorsal raphe nucleus, potentially leading to a decrease in the release of 5-HT in specific forebrain areas.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids inhibit transient LES relaxations through a CB1-dependent mechanism, as reported in a study from the Journal of Cannabis and Cannabinoid Research. These findings are significant since transient LES relaxations are the main mechanism behind gastroesophageal reflux disease.

Cannabis Sativa for GI Issues

Conclusion

Numerous studies suggest that the benefits of cannabinoids extend beyond the well-known psychoactive compound THC, including non-psychoactive molecules like CBD and others, which have received comparatively less attention. The cannabis plant interacts with the GI system via the ECS, triggering various functions that can help manage symptoms of specific GI conditions.

Frequently Asked Questions

What can you expect when buying from online cannabis stores?

1. Accessing your cannabis products in Canada from an online store opens up many options featuring both timeless favorites and new products.
2. You can anticipate additional benefits such as special offers, reliable payment methods, and shipping options covering most provinces.
3. Essential resources, such as a blog section or contact page, provide customers with insights or assistance during their shopping experience.
4. As part of the purchase process, you’ll need to verify or confirm your age by presenting identification.
5. Some stores include taxes in their product prices, while others calculate it at checkout.
6. Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two primary forms of measurement: metric and imperial units. On a cannabis site, you’ll encounter measurements in grams or ounces, allowing you to find products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis come from the same plant species, yet their differing effects and intended applications set them apart. Medical cannabis acts as a therapeutic aid for specific health conditions, often containing a higher CBD composition compared to its recreational counterpart.

Are there ready-made joints available in a cannabis store?

Yes. These come in the form of pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient options for those who prefer their cannabis ready to use. There is a growing trend in the popularity of pre-rolled joints infused with cannabis concentrates.

Do cannabis online stores have a physical shop?

Not all online stores maintain physical locations, meaning you can have your purchases delivered directly to your doorstep rather than picking them up from a physical outlet after placing an online order.

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